Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Platelets and Megakaryocytes in Mammalian Biology
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"New Regulators of Signaling in Megakaryopoiesis"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Platelets Locally Release aIIbß3/CD9-rich Membrane Patches to Promote Thromboinflammation"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Platelets, PANoptosis and Respiratory Viruses"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"VWF-Platelet Interactions in Cardiovascular Settings"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Megakaryopoiesis And Platelet Biogenesis in the Spleen in Sepsis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Amyloid Peptides in Platelet Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Platelet Regulation of Circulating Monocyte Immune-Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Harnessing G6b-B Using CAPRIs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Platelet Stress Responses: Guardians of the Galaxy "
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"The 100 Platelet Releasates Project (100 PREPs)"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Platelet Integrin Signaling: New Players/Concepts and Novel Models/Methods For Studies in vivo "
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Procoagulant Platelets Have a Distinct Transcriptome That Identifies the Large GTPase Dynamin as a Driver In Their Formation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Generation of Functionally Opposing Platelet Subpopulations After Radiation-Mediated Bone Marrow Remodeling and Hematopoietic Stem Cell Transplantation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Interface Between Large Scale Manufacturing and Quality Control of iPSC-Platelets"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Iron-Dependent Lipid Turnover Curtails Megakaryocytic Fate in Hematopoietic Stem Cells"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Making Platelets in vitro : Confronting Truth and Reality With Hypes and Hopes"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Spatiotemporal Analysis of the Mammalian Megakaryocyte System Reveals Distinct Subpopulations and Developmental Dynamics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Platelets As Blood ‘Sentinels’ of Variant DNA"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"KIFC1-Dependent Centrosome Clustering Initiates Proplatelet Formation From Megakaryocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Influence of JAK2V617F Mutation on the Glycosylation Profile of a2 and ß1 Integrins in Megakaryocytes and Platelets"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Imaging and New Technology Evaluating Platelet and Megakaryocyte Function
6:00 pm - 6:20 pm
"Intravital Visualization of Platelets and Thrombosis in Infectious Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Biomaterial Thrombosis-on-a-Chip For Real-Time Evaluation of Platelet Responses To Materials"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Mpl Endocytosis in Megakaryocyte Homeostasis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Platelet Production via Membrane Budding"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Platelet Production
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Regulation of Fatty Acids as a Novel Mechanism Controlling Megakaryopoiesis and Platelet Production"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Modifying Ligand-Receptor Interactions to Explore the Pleiotropy of Thrombopoietin Signaling"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Ribosomal Biogenesis Inhibition Facilitates Megakaryocyte/Platelet-Biased Haematopoiesis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Platelet Glycoprotein V Spatio-Temporally Controls Fibrin Formation."
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Role of Phosphoinositides PI3P and PI4P in Platelet Production"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Megakaryopoiesis, Thrombopoiesis And Clotting: Transcriptional Regulation of Cell Identity And Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Silk Fibroin Bionks for 3D Bioprinting Soft Living Bone Marrow Structures Promote Platelet Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Neutrophils “Plucking ” on Megakaryocytes Drives Platelet Production and Boosts Cardiovascular Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Retraining and Constraining Platelets and Megakaryocytes
6:00 pm - 6:20 pm
"Novel Insights Into Shp1 and Shp2 In Megakaryopoiesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Interferon Response Elements Mediate Platelet Activation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Platelet Cargo And Receptors in Orchestrating The Fibrinolytic Response"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Expansion Microscopy for Ultrastructural Analysis of Megakaryocytes and Platelets"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Newly Identified Roles for Piezo1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Highly Efficient Platelet Generation in vitro in Lung Vasculature And Microfluidics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Platelets and Ferric Iron"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Targeting GPVI in Thrombosis And Beyond"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Platelet-Directed Gene Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Platelets And The Immune Response At Single-Cell Resolution"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CS585 is the First Stable IP Receptor Agonist That Potently and Selectively Attenuates Platelet Activity and Thrombosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Trans-Megakaryocyte Migration Modulates Neutrophil Inflammatory Capacity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Extending GWAS Data to Functional Outcomes
6:00 pm - 6:20 pm
"Ultra-Rare Genetic Disorders: Nature’s Experiments on Platelet Formation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Inherited Genetic Errors That Impact Platelet Biology"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Genetic Contributions To Thrombocytopenia"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"A Common, Racially Diverse Protease Activated Receptor 4 Functional Variant Impacts Ischemic Stroke Outcomes: Evidence for a Pharmacogenetic Effect"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Multi-Omic Profiling Reveals Metabolic Alterations as Novel Treatment Targets for Myeloproliferative Neoplasms"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure