Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Platelets and Megakaryocytes in Mammalian Biology
Discussion Leader: Martine Jandrot-Perrus (Laboratory for Vascular Translational Science (LVTS), Paris Diderot University, France)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Hana Raslova (INSERM UMR 1287, Gustave Roussy, Villejuif, France)
"New Regulators of Signaling in Megakaryopoiesis"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Bernhard Nieswandt (University Clinic, University of Würzburg, Germany)
"Platelets Locally Release aIIbß3/CD9-rich Membrane Patches to Promote Thromboinflammation"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Platelets Under Duress
Discussion Leader: Michele Lambert (The Children's Hospital of Philadelphia, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Milka Koupenova (UMass Chan Medical School, United States)
"Platelets, PANoptosis and Respiratory Viruses"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Sophie Susen (Lille University Hospital, France)
"VWF-Platelet Interactions in Cardiovascular Settings"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Mark Looney (University of California, San Francisco, United States)
"Megakaryopoiesis And Platelet Biogenesis in the Spleen in Sepsis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ilaria Canobbio (University of Pavia, Italy)
"Amyloid Peptides in Platelet Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Paul Armstrong (Queen Mary University of London, United Kingdom)
"Platelets in Trauma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Craig Morrell (Aab Cardiovascular Research Institute (CVRI), University of Rochester School of Medicine, United States)
"Platelet Regulation of Circulating Monocyte Immune-Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yotis Senis (EFS, Inserm, University of Strasbourg, France)
"Harnessing G6b-B Using CAPRIs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Hervé Falet (Versiti Blood Research Institute, United States) and Antonija Jurak Begonja (University of Rijeka, Croatia)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Inside Platelets
Discussion Leader: Debra Newman (Versiti Blood Center of Wisconsin, United States)
6:00 pm - 6:20 pm
John Hwa (Yale Medical School, United States)
"Platelet Stress Responses: Guardians of the Galaxy "
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Patricia Maguire (University College Dublin, Ireland)
"The 100 Platelet Releasates Project (100 PREPs)"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Wolfgang Bergmeier (University of North Carolina at Chapel Hill, United States)
"Platelet Integrin Signaling: New Players/Concepts and Novel Models/Methods For Studies in vivo "
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Vivien Chen (University of Sydney, Australia)
"Procoagulant Platelets Have a Distinct Transcriptome That Identifies the Large GTPase Dynamin as a Driver In Their Formation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Kristina Mott (University Hospital Würzburg, Germany)
"Generation of Functionally Opposing Platelet Subpopulations After Radiation-Mediated Bone Marrow Remodeling and Hematopoietic Stem Cell Transplantation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Manufacturing Plant
Discussion Leader: Joseph Italiano (Boston Children's Hospital, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Koji Eto (Kyoto University, Japan)
"Interface Between Large Scale Manufacturing and Quality Control of iPSC-Platelets"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Britta Will (Albert Einstein College of Medicine, United States)
"Iron-Dependent Lipid Turnover Curtails Megakaryocytic Fate in Hematopoietic Stem Cells"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Cedric Ghevaert (University of Cambridge, United Kingdom)
"Making Platelets in vitro : Confronting Truth and Reality With Hypes and Hopes"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jiaxi Zhou (Institute of Radiation Medicine of Chinese Academy of Medical Science & Peking Union Medical College, China)
"Spatiotemporal Analysis of the Mammalian Megakaryocyte System Reveals Distinct Subpopulations and Developmental Dynamics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Beth Psaila (University of Oxford, United Kingdom)
"Platelets As Blood ‘Sentinels’ of Variant DNA"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Isabelle Becker (Boston Children’s Hospital and Harvard Medical School, United States)
"KIFC1-Dependent Centrosome Clustering Initiates Proplatelet Formation From Megakaryocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Katya Ravid (Boston University School of Medicine, United States)
"Influence of JAK2V617F Mutation on the Glycosylation Profile of a2 and ß1 Integrins in Megakaryocytes and Platelets"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Imaging and New Technology Evaluating Platelet and Megakaryocyte Function
Discussion Leader: Diane Krause (Yale University, United States)
6:00 pm - 6:20 pm
Craig Jenne (University of Calgary, Canada)
"Intravital Visualization of Platelets and Thrombosis in Infectious Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Anna Waterhouse (University of Sydney, Australia)
"Biomaterial Thrombosis-on-a-Chip For Real-Time Evaluation of Platelet Responses To Materials"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Hervé Falet (Versiti Blood Research Institute, United States)
"Mpl Endocytosis in Megakaryocyte Homeostasis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Samir Taoudi (The Walter and Eliza Hall Institute, Australia)
"Platelet Production via Membrane Budding"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Platelet Production
Discussion Leader: Karina Yazdanbakhsh (New York Blood Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Kellie Machlus (Harvard Medical School and Boston Children's Hospital, United States)
"Regulation of Fatty Acids as a Novel Mechanism Controlling Megakaryopoiesis and Platelet Production"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ian Hitchcock (University of York, United Kingdom)
"Modifying Ligand-Receptor Interactions to Explore the Pleiotropy of Thrombopoietin Signaling"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Vijay Bhoopalan (John curtin school of medical research, ANU, Australia)
"Ribosomal Biogenesis Inhibition Facilitates Megakaryocyte/Platelet-Biased Haematopoiesis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Sarah Beck (University of Würzburg, Germany)
"Platelet Glycoprotein V Spatio-Temporally Controls Fibrin Formation."
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Antonija Jurak Begonja (University of Rijeka, Croatia)
"The Role of Phosphoinositides PI3P and PI4P in Platelet Production"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mattia Frontini (University of Exeter, United Kingdom)
"Megakaryopoiesis, Thrombopoiesis And Clotting: Transcriptional Regulation of Cell Identity And Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Christian Di Buduo (University of Pavia, Italy)
"Silk Fibroin Bionks for 3D Bioprinting Soft Living Bone Marrow Structures Promote Platelet Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tobias Petzold (LMU Munich, Germany)
"Neutrophils “Plucking ” on Megakaryocytes Drives Platelet Production and Boosts Cardiovascular Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Retraining and Constraining Platelets and Megakaryocytes
Discussion Leader: Katya Ravid (Boston University School of Medicine, United States)
6:00 pm - 6:20 pm
Alexandra Mazharian (Inserm U1255, Etablissement Français du Sang, Strasbourg, France)
"Novel Insights Into Shp1 and Shp2 In Megakaryopoiesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Matthew Rondina (University of Utah, United States)
"Interferon Response Elements Mediate Platelet Activation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Nicola Mutch (University of Aberdeen, United Kingdom)
"Platelet Cargo And Receptors in Orchestrating The Fibrinolytic Response"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Maximillian Carlino (Yale University, United States)
"Expansion Microscopy for Ultrastructural Analysis of Megakaryocytes and Platelets"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Vittorio Abbonante (Fondazione IRCCS Policlinico San Matteo , Italy)
"Newly Identified Roles for Piezo1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Nature of the Clot
Discussion Leader: Samantha Montague (University of Birmingham, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Alastair Poole (University of Bristol, United Kingdom)
"Highly Efficient Platelet Generation in vitro in Lung Vasculature And Microfluidics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Katsue Suzuki-Inoue (University of Yamanashi, Japan)
"Platelets and Ferric Iron"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Pierre Mangin (EFS, France)
"Targeting GPVI in Thrombosis And Beyond"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ute Modlich (Paul-Ehrlich-Institute, Germany)
"Platelet-Directed Gene Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Leo Nicolai (LMU Munich, Germany)
"Platelets And The Immune Response At Single-Cell Resolution"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Michael Holinstat (University of Michigan, United States)
"CS585 is the First Stable IP Receptor Agonist That Potently and Selectively Attenuates Platelet Activity and Thrombosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Pierre Cunin (Boston Children's Hospital, United States)
"Trans-Megakaryocyte Migration Modulates Neutrophil Inflammatory Capacity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Extending GWAS Data to Functional Outcomes
Discussion Leader: Paula Heller (University of Buenos Aires. CONICET, Argentina)
6:00 pm - 6:20 pm
Kathleen Freson (KU Leuven, Belgium)
"Ultra-Rare Genetic Disorders: Nature’s Experiments on Platelet Formation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Neil Morgan (University of Birmingham, United Kingdom)
"Inherited Genetic Errors That Impact Platelet Biology"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jose Maria Bastida (Complejo Asistencial Universitario de Salamanca, Spain)
"Genetic Contributions To Thrombocytopenia"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Robert Campbell (University of Utah, United States)
"A Common, Racially Diverse Protease Activated Receptor 4 Functional Variant Impacts Ischemic Stroke Outcomes: Evidence for a Pharmacogenetic Effect"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Stephen Oh (Washington University School of Medicine, United States)
"Multi-Omic Profiling Reveals Metabolic Alterations as Novel Treatment Targets for Myeloproliferative Neoplasms"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure